Helicoidal transfer matrix model for inhomogeneous DNA melting
نویسندگان
چکیده
منابع مشابه
Helicoidal transfer matrix model for inhomogeneous DNA melting.
An inhomogeneous helicoidal nearest-neighbor model with continuous degrees of freedom is shown to predict the same DNA melting properties as traditional long-range Ising models, for free DNA molecules in solution, as well as superhelically stressed DNA with a fixed linking number constraint. Without loss of accuracy, the continuous degrees of freedom can be discretized using a minimal number of...
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Maria Barbi, Simona Cocco and Michel Peyrard 1 Istituto Nazionale di Fisica Nucleare, Dipartimento di Fisica, Universitá degli Studi di Firenze, Largo E. Fermi, 2 50125 Firenze, Italy 2 Dipartimento di Scienze Biochimiche Universitá di Roma ”La Sapienza” P.le A. Moro, 5 00185 Roma, Italy 3 Laboratoire de Physique, CNRS URA 1325, Ecole Normale Supérieure de Lyon, 46 Allée d’Italie, 69364 Lyon Ce...
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We study the static and dynamical properties of DNA in the vicinity of its melting transition, i.e., the separation of the two strands upon heating. The investigation is based on a simple mechanical model which includes the helicoidal geometry of the molecule and allows an exact numerical evaluation of its thermodynamical properties. Dynamical simulations of long-enough molecular segments allow...
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ژورنال
عنوان ژورنال: Physical Review E
سال: 2006
ISSN: 1539-3755,1550-2376
DOI: 10.1103/physreve.73.011908